Antibiotic prophylaxis for leptospirosis

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Regular use of weekly doxycycline 200 mg oral therapy has increased odds for nausea and vomiting with unclear benefit in reducing Leptospira seroconversion or clinical consequences of infection. If it is efficacious in reducing disease, it may be more so in travellers rather than in residents of an endemic area.

Leptospira infection is a global zoonosis caused by spirochetes of the genus Leptospira. It causes endemic disease among agricultural workers and others regularly exposed to flooded fields and livestock, or other sources of animal urine. Outbreaks of leptospirosis also occur among immune-naive individuals who may be exposed because of changing environmental conditions, travel, or occupational or recreational activities, for example. This review assesses the evidence for or against use of antibiotic prophylaxis against Leptospira infection.

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