Antibiotic prophylaxis for preventing burn wound infection

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There is some evidence from RCTs suggesting that the use of silver sulfadiazine when used directly on the burn is associated with significantly increased rates of infection and longer length of hospital stay compared with dressings or skin substitutes. However, studies were at unclear or high risk of bias.  There is insufficient evidence overall to draw firm conclusions on the effectiveness of antibiotics on the rates of burn wound infection.

Burn wound infections delay the healing process, are associated with increased scarring and invasive infections and can also result in death. The aim of the systematic review was to assess the effectiveness of antibiotic prophylaxis on the rates of burn wound infections.

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