Available evidence of association between Zika Virus and Microcephaly

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There are some evidence available through mice models and direct isolation of ZIKV in affected pregnancies on kindly causal relationship but not convincible enough.

 Zika virus (ZIKV) is a mosquito‑borne flavivirus related to dengue, yellow fever, and Japanese encephalitis. In 2015, physicians in Brazil found patients with a “dengue‑like syndrome” and ZIKV was identified as the cause. Later, physicians began to report a surge in the number of microcephaly among newborns, possibly linked to ZIKV infection during the mothers´ pregnancy. Thus, a Public Health Emergency of International Concern was dispatched to explore the suspected association between ZIKV and microcephaly. This study aims to clarify the possible association between ZIKV and microcephaly and understand where we are regarding the causation between mild maternal clinical features and severe fetal microcephaly. Results highlight a) ZIKV infection and clinical manifestation,  arguing confirmation of infection remains challenging; b)Testing techniques while the mechanism of microcephaly is uncertain; c) The flexible definition of microcephaly, which hinders an accurate diagnosis; d) Current evidence regarding association between ZIKV and microcephaly, as studies lack robust evidence and e) Enlightenment from global movement tracking by molecular epidemiology, claiming it is too early for conclusions about ZIKV infection.

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