Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis
The addition of an aminoglycoside to a beta lactam does not improve the clinical efficacy achieved with the beta lactam alone. However, the combination therapy of an aminoglycoside and a beta lactam was associated with an increased risk of renal damage and high cost in resource poor setting therefore should be discouraged.
Infections caused by bacteria and requiring hospitalization are a leading cause of preventable death. The beta lactam antibiotics and the aminoglycosides kill bacteria by different means, therefore there combination maybe a more effective treatment. This review aimed to compared intravenous treatment with a beta lactam versus treatment with a beta lactam plus an aminoglycoside, to establish effectiveness and safety.
Adults, Both sexes, Cardiovascular diseases, Child health, Children, Epidemic, Gastrointestinal infections, Genitourinary and gynaecologic, Health, Infections and infectious diseases (all), Neoplasms and hematologic diseases, Respiratory infections, Skin infections, Zoonotic and other parasitic infections