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Combined and alternating paracetamol and ibuprofen therapy for febrile children

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There is some evidence to support the use of alternating and combination therapy compared with monotherapy alone at reducing temperatures in children with a fever. However, on the outcome of child discomfort, the evidence still remains unsatisfactory. Furthermore, there is insufficient evidence …

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Early versus delayed dressing removal after primary closure of clean and clean-contaminated surgical wounds

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Evidence on the effectiveness of early dressing removal compared with dressing surgical wounds beyond 48 hours post-surgery is based on very low quality evidence from only three randomised controlled trials.
There is contradictory evidence on the importance of dressing surgical wounds beyond …

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Prophylactic antibiotics for penetrating abdominal trauma

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There is no evidence from randomised controlled trials on the benefits and harms for the use of antibiotics for abdominal trauma. Due to the lack of randomised controlled trials on the effectiveness of antibiotics for abdominal injuries, future research should focus on …

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Debridement for surgical wounds

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There is insufficient evidence on the efficacy of various methods of debridement on wound healing and the rate of debridement to guide clinical practice. There are very few large high quality trials evaluating the efficacy of various methods of debridement that have …

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Single dose oral ibuprofen for acute postoperative pain in adults

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There is a large amount of evidence available from thirty-five reviews on the efficacy of single dose oral analgesics for acute postoperative pain in adults.  Additionally, the overview of reviews found a wealth of information on drugs that had no data, inadequate …

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Community-based supplementary feeding for promoting the growth of children under five years of age in low and middle income countries

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There is insufficient evidence to support the community-based supplementary feeding for promoting the growth of children under 5 years old in developing countries. This is because of the scarcity of available studies and their heterogeneity, which makes it difficult to reach any firm …

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Intermittent iron supplementation for improving nutrition and development in children under 12 years of age

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There is evidence to suggest that intermittent iron supplementation when compared to placebo or no intervention, is effective in reducing the risk of anaemia in children ≤12 years of age. However, daily supplementation is more effective than intermittent iron supplementation in preventing and …

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Antibiotics for preventing infection in open limb fractures

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There is evidence that antibiotics reduce the incidence of early infections in open fractures of the limbs.
Antibiotics are routinely used in clinical practice as an adjunct to other treatment and management interventions in the prevention of infections resulting from open limb fractures. …

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Pulse oximetry for perioperative monitoring

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There is evidence to support use of pulse oximetry for detecting hypoxaemia and other related events. However, there is no evidence to suggest that  oximetry affects patient related outcomes. 
The use of pulse oximetry in perioperative monitoring is very common in routine …

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Tissue adhesives for closure of surgical incisions

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There is evidence to support the use of sutures over tissue adhesives for minimising dehiscence.
Sutures, staples and adhesive tapes are often used in wound closure however; each method has some advantages and disadvantages. The aim of the review was to determine …

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