Combined and alternating paracetamol and ibuprofen therapy for febrile children

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There is some evidence to support the use of alternating and combination therapy compared with monotherapy alone at reducing temperatures in children with a fever. However, on the outcome of child discomfort, the evidence still remains unsatisfactory. Furthermore, there is insufficient evidence to ascertain which combination or alternative therapy would be more useful at treating fevers in children.There were no serious adverse events reported that were directly attributed to the medications used.

There is inconsistent evidence on the effects of using monotherapy compared to combination therapies for the treatment of fever in children. The aim of the review was to assess the safety and effectiveness of combining paracetamol and ibuprofen or alternating them as consecutive treatments compared with monotherapy for treating fever in children.

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