EPA-registered repellents for mosquitoes transmitting emerging viral disease

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The conventional repellent picaridin has the strongest data to support its use as a second-line agent, as a mosquito repellent. IR3535 and oil of lemon eucalyptus are reasonably effective natural products. Citronella, catnip, and 2-undecanone offer limited protection or have limited data.

Mosquitoes represent a potential threat in the spread of viral diseases, including Zika virus. The Aedes aegypti, Aedes albopictus, and Culex species mosquitoes are endemic to the United States and can transmit a variety of viral diseases. A systematic review of the literature was carried out to identify which EPA-registered personal mosquito repellent provides the best protection from A. aegypti, A. albopictus, and Culex spp. mosquitoes. Data from 62 published reports of EPA-registered mosquito repellents was identified. The quality of the studies was not considered. The data was very mixed in terms of sample size (generally small), controls, study design, specific product, density of mosquitoes, mosquito species, and environment.

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