Immunoglobulins for preventing hepatitis A

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Immunoglobulins seem effective for preventing hepatitis A in both children and adults. However, the evidence, on which the conclusion is based, is not strong as the included trials appear to have risk of bias and their number is insufficient.

Hepatitis A is a common, contagious viral disease in low-income countries. Hepatitis A is transmitted primarily by faecal-oral spread from person to person. Passive immunoprophylaxis for hepatitis A using immunoglobulin preparations was essential for prevention before the development of a specific hepatitis A vaccine (active immunization). This review assesses the beneficial and harmful effects of the pre- and post-exposure prophylaxis with immunoglobulins for preventing hepatitis A.

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