Intermittent versus daily therapy for treating tuberculosis in children

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Evidence from four randomised trials was insufficient to determine that the use of daily drug treatment was more effective than intermittent (twice- or thrice-weekly) treatment for children with tuberculosis.

Childhood tuberculosis is a neglected global public health problem. Rifampicin-containing drugs given daily for six months cure over 90% of infected children, but poor adherence and supervision reduces treatment success. The aim of the review was to establish if daily anti-tuberculosis treatments were better than intermittent treatments.

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