Vaccines for preventing invasive salmonella infections in people with sickle cell disease

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It is expected that salmonella vaccines may be useful in people with sickle cell disease, especially in resource-poor settings where the majority of those who suffer from the condition are found. Unfortunately, there are no randomized controlled trials on the efficacy and safety of the different types of salmonella vaccines in people with sickle cell disease.

Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease, especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This review determines whether routine administration of salmonella vaccines to people with sickle cell disease reduces the morbidity and mortality associated with infection.

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