» Claire Allen

Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children

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In children admitted to hospital with diarrhoea, reduced osmolarity ORS [total osmolarity ≤ 250 mmol/L with reduced sodium] when compared to WHO standard ORS [90 mmol/L sodium, 111 mmol/L glucose, total osmolarity 311 mmol/L] is associated with fewer unscheduled intravenous fluid infusions, …

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Antibiotic prophylaxis for leptospirosis

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Regular use of weekly doxycycline 200 mg oral therapy has increased odds for nausea and vomiting with unclear benefit in reducing Leptospira seroconversion or clinical consequences of infection. If it is efficacious in reducing disease, it may be more so in …

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Oral treatments for fungal infections of the skin of the foot

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The evidence suggests that terbinafine is more effective than griseofulvin and that terbinafine and itraconazole are more effective than no treatment.
About 15% of the population have fungal infections of the feet (tinea pedis or athlete’s foot). While there are many clinical …

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Topical treatments for fungal infections of the skin and nails of the foot

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Placebo-controlled trials of allylamines and azoles for athlete’s foot consistently produce much higher percentages of cure than placebo. Allylamines cure slightly more infections than azoles and are now available OTC [over the counter]. Further research into the effectiveness of antifungal agents …

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Antibiotics for treating scrub typhus

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There are no obvious differences between tetracycline, doxycycline, telithromycin, or azithromycin; rifampicin may be better than tetracycline in areas where scrub typhus appears to respond poorly to standard anti-rickettsial drugs.
Scrub typhus is a bacterial infection transmitted by chiggers (mites). The infection …

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Interventions for trachoma trichiasis

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No trials show interventions for trichiasis prevent blindness. Certain interventions have been shown to be more effective at eliminating trichiasis.
Repeated infections cause scarring of the conjunctiva of the upper eyelid, which causes the eyelid to turn in (entropion) so that the …

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Face washing promotion for preventing active trachoma

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Evidence from one trial suggests that face washing can be effective in increasing facial cleanliness and in reducing severe trachoma, but its effect in reducing active trachoma is inconclusive. In another trial, there was no evidence of effect of face washing …

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Environmental sanitary interventions for preventing active trachoma

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The role of insecticide spray as a fly control measure in reducing trachoma remains unclear. There is some evidence from two trials that insecticides are effective in reducing transmission of trachoma, but not demonstrated in another trial that also used insecticides. …

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Antibiotics for trachoma

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The review found some evidence that antibiotics reduce trachoma. Ointment is neither better nor worse than tablets.
In 1997, WHO launched an initiative on trachoma control based on the SAFE strategy (surgery, antibiotics, facial cleanliness, and environmental improvement). This review aims to …

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Antibiotics versus placebo for acute bacterial conjunctivitis

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Acute bacterial conjunctivitis is frequently a self-limiting condition, but the use of antibiotics is associated with modestly improved rates of clinical and microbiological remission compared to placebo.
Acute bacterial conjunctivitis is an infective condition in which the eyes become red and inflamed. …

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