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The role of Evidence Synthesis in COVID-19

Ciara Keenan image for slider Leaflet app

Authors: Ciara Keenan, Damian Fogarty, Samantha Cheng and Chris Noone
Introduction: On 31 December 2019, the Wuhan Health Commission reported atypical pneumonia to the World Health Organisation (WHO) in patients who had been experiencing symptoms since mid-December. Shortly thereafter, a new RNA virus, with similarity to a coronavirus …

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Ward closure to control outbreaks of infectious diseases among hospitalized patients in acute care settings: effects are uncertain

Citation: Wong H, Eso K, Ip A, et al. Use of ward closure to control outbreaks among hospitalized patients in acute care settings: a systematic review. Systematic Reviews 2015; 4: 152
What is this? Ward closure in acute care facilities might be used to control outbreaks …

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Fatores associados à disponibilidade dos profissionais de saúde para trabalhar durante uma emergência de saúde pública devido à gripe

Citation: Devnani M. Factors associated with the willingness of health care personnel to work during an influenza public health emergency: an integrative review. Prehospital and Disaster Medicine 2012; 27(6): 551-66
De que se trata? A eficácia da resposta de saúde pública a uma emergência, como a que …

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Facteurs associés à la volonté du personnel de santé de travailler pendant une urgence publique liée à la grippe

Citation: Devnani M. Factors associated with the willingness of health care personnel to work during an influenza public health emergency: an integrative review. Prehospital and Disaster Medicine 2012; 27(6): 551-66
De quoi s’agit-il ? Une réponse efficace de santé publique à une urgence telle que celle causée …

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Chloroquine : les preuves pré-cliniques sont suffisantes pour justifier la recherche clinique sur ses effets sur le COVID-19

Citation: Cortegiani A,  Ingoglia G,  Ippolito M,  et al. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. Journal of Critical Care 2020  [Epub ahead of print]
De quoi s’agit-il ? On connaît pas, pour le moment (26 mars 2020), de …

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Factores asociados con la disposición de los trabajadores de la salud a trabajar durante una emergencia de salud pública por influenza

Citation: Devnani M. Factors associated with the willingness of health care personnel to work during an influenza public health emergency: an integrative review. Prehospital and Disaster Medicine 2012; 27(6): 551-66
¿Qué es esto? Una respuesta efectiva de salud pública a una emergencia como la causada por COVID-19 …

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Cloroquina: la evidencia preclínica es suficiente para justificar la investigación clínica sobre sus efectos para COVID-19

Citation: Cortegiani A,  Ingoglia G,  Ippolito M,  et al. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. Journal of Critical Care 2020  [Epub ahead of print]
¿Qué es esto? Actualmente (26 de marzo de 2020), no existe un tratamiento efectivo …

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Pharmacological interventions for the treatment of delirium in critically ill adults

Citation: Burry L, Hutton B, Williamson DR, et al. Pharmacological interventions for the treatment of delirium in critically ill adults. Cochrane Database of Systematic Reviews 2019; (9): CD011749
What is this? Some patients with COVID-19 will become critically ill and need treatment in an intensive care …

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压力控制通气与通气量控制通气在治疗呼吸衰竭的效果:未确定有任何重要差异

Citation: Chacko B, Peter J V, Tharyan P, et al. Pressure-controlled versus volume-controlled ventilation for acute respiratory failure due to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Cochrane Database of Systematic Reviews 2015; (1): CD008807
这是什么?部分新冠肺炎的患者会发生呼吸衰竭,并需要呼吸支持。这可以通过重症监护室的机械通气提供,但有可能会引发并发症。通过不同技术控制机械通气中的气压和通气量可预防机械通气带来的并发症。
在这篇Cochrane系统综述中,作者检索了比较压力控制与通气量控制通气对成人呼吸衰竭影响的随机和半随机对照试验。不限发布语言和状态,他们自2014年10月开始检索。他们发现三例随机对照试验(总共1089位参与者)。
有效的:未提及。
无效的:未提及。
未确定的:目前尚未确定压力控制与通气量控制通气对成人呼吸衰竭案例的作用在以下方面有差异:重症监护室死亡率,压力性损伤,机械通气时长,机械通气感染或出院后生活质量。

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无创正压通气治疗可用于帮助机械通气患者撤机

Citation: Burns KE A, Meade M O, Premji A, Adhikari NKJ. Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure. Cochrane Database of Systematic Reviews 2013; (12): CD004127
这是什么?部分新冠肺炎的患者会发生呼吸衰竭,并需要呼吸支持。这可以通过重症监护室的机械通气提供,但有可能会引发并发症。无创正压通气(如与正压呼吸机相联的面罩)可用于帮助患者脱离机械通气以减少这些并发症的发生。
在这篇Cochrane的系统综述中,作者通过检索随机对照试验和半随机对照试验,将早期拔管并立即进行无创正压通气治疗的成人呼吸衰竭案例与有创正压通气治疗的案例在效果上进行了比较。不限发布语言,他们自2013年5月开始检索。纳入了十五个随机对照试验和一个半随机对照试验(总共994位参与者)。三分之二的受试者患有慢性阻塞性肺疾病(COPD)所导致的呼吸衰竭。
有效的:无创正压通气支持相比较于有创正压通气,可以降低死亡率、拔管失败率,减少重症监护及住院时间,降低通气时间总长、气管切开术和再插管率。然而,这些结论主要是就COPD患者的临床试验得出的
无效的:未提及。
不确定的:未提及。

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