Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis
The addition of an aminoglycoside to a beta lactam does not improve the clinical efficacy achieved with the beta lactam alone. However, the combination therapy of an aminoglycoside and a beta lactam was associated with an increased risk of renal damage and high cost in resource poor setting therefore should be discouraged.
Infections caused by bacteria and requiring hospitalization are a leading cause of preventable death. The beta lactam antibiotics and the aminoglycosides kill bacteria by different means, therefore there combination maybe a more effective treatment. This review aimed to compared intravenous treatment with a beta lactam versus treatment with a beta lactam plus an aminoglycoside, to establish effectiveness and safety.
We’ve already reached tens of thousands of people with plain language summaries of systematic reviews. If you’d like to help us to continue our work, please consider a donation.
Donate with PayPal
You can also donate through the Charities Aid Foundation (CAF) here. If you are based in the USA and want to make a tax-deductable donation, please donate to Evidence Aid via the British Schools and Universities Foundation.