Chloroquine: pre-clinical evidence is sufficient to justify clinical research into its effects for COVID-19
Citation: Cortegiani A, Ingoglia G, Ippolito M, et al. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. Journal of Critical Care 2020 [Epub ahead of print]
What is this? Currently (26 March 2020), there is no known effective treatment for COVID-19. Various drugs have been suggested as possible treatments, including chloroquine.
In this rapid systematic review, the authors searched for studies of any design evaluating the efficacy and safety of chloroquine and chloroquine-related formulations for patients with COVID-19 pneumonia (including ongoing studies) or in-vitro studies. They did not limit by time or language of publication and did their search on 1 March 2020. They included one narrative letter, one in-vitro study, one editorial, one expert consensus paper and two national guideline documents. They also identified 23 ongoing clinical trials.
What works: Nothing noted.
What doesn’t work: Nothing noted.
What’s uncertain: The potential benefits and harms of chloroquine for patients with COVID-19 are uncertain but the existing pre-clinical evidence is sufficient to justify clinical research into its effects.
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