Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease

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This review of 17 randomized controlled trials compared the reliability, ease of use and speed of insertion of different parenteral access methods. Peripheral intravenous access remains most effective, but intraosseous and subcutaneous routes are viable alternatives.

Dehydration is an important cause of death in Ebola virus disease (EBV).  None of the trials identified involved patients with EVD, but they covered a range of different medical settings and reported on different outcomes. In view of the nature of EVD outbreaks, methods for achieving parenteral access need to be simple, easy and quick, and not put healthcare workers at unnecessary risk.  The opportunities to use intraosseous and subcutaneous methods as alternatives to intravenous administration may be valuable.

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