Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth
The present data suggest that supplementation with n-3 long chain polyunsaturated fatty acids (LC-PUFA) in women with high-risk pregnancies reduced the risk of early preterm delivery in the fatty acid-supplemented group compared with the placebo group, while no other effects on pregnancy outcomes were detected.
LC-PUFTA intake during pregnancy has been considered to have positive effects on pre-eclampsia, pregnancy-induced hypertension or intra-uterine growth retardation, and is essential for optimal neural development. This review aimed to evaluate the effects of LC-PUFTA supplementation to the diets of women with high-risk pregnancies on pregnancy outcomes and growth measures at birth. Four randomized or quazi-randomized trials with 1264 participants were included in this review, independently reviewed according to inclusion criteria by two separate reviewers. Results showed no evidence for the effect of LC-PUFTA on the duration of pregnancy or the percentage of preterm deliveries however, a significantly lower rate of early preterm delivery was observed. No significant difference in infant birth weight, rate of low birth weight and recurrence of intra-uterine growth retardation was observed. Other pregnancy outcomes were noted to be of little difference in the control and supplementation groups.
Adults, Both sexes, Cardiovascular conditions, Child health, Children, Endocrine and metabolic conditions, Female, Health, Maternal and perinatal health, Neonates/infants, Nervous system and neurologic conditions, Non-communicable diseases (all), Nutrition, Pregnant/lactating women