Sinonasal pathophysiology of SARS‐CoV‐2 and COVID‐19 (search done: 30 March 2020)

Citation: Gengler I, Wang JC, Speth MM, et al. Sinonasal pathophysiology of SARS‐CoV‐2 and COVID‐19: A systematic review of the current evidence. Laryngoscope Investigative Otolaryngology. 2020 Apr 10.

What is this? One possible route of transmission of the SARS-Cov-2 virus is through the sinonasal tract of patients with COVID-19.

In this rapid review, the authors searched for studies that evaluated nasal and sinonasal pathophysiology in COVID-19 patients. They restricted their search to articles published in English or Chinese and did their most recent search on 30 March 2020. They included 19 studies. They also identified an additional two studies, which are awaiting assessment.

What was found: Based on the studies available at the time of this review, the sinonasal tract cavity may be an important site for infection and sinonasal viral shedding may be an important transmission mechanism, including for healthcare‐associated infection.

Based on the studies available at the time of this review, anosmia without nasal obstruction may be a highly specific indicator of COVID‐19.

 

Disclaimer: This summary has been written by staff and volunteers of Evidence Aid in order to make the content of the original document accessible to decision makers who are searching for the available evidence on the coronavirus (COVID-19) but may not have the time, initially, to read the original report in full. This summary is not intended as a substitute for the medical advice of physicians, other health workers, professional associations, guideline developers, or national governments and international agencies. If readers of this summary think that the evidence that is presented within it is relevant to their decision-making they should refer to the content and details of the original article, and the advice and guidelines offered by other sources of expertise, before making decisions. Evidence Aid cannot be held responsible for any decisions made about the coronavirus (COVID-19) on the basis of this summary alone.

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