Systematic Reviews in Progress

The Cochrane Collaboration

The Cochrane Collaboration is currently in the process of producing the following systematic review, the protocol is scheduled for publication on 14 November, with a view to the full article being published on 5 December in The Cochrane Library:

Comparison of parenteral routes for fluid administration: protocol for a rapid systematic review of randomised controlled trials – Many patients with Ebola Virus Disease (EVD) suffer from severe dehydration caused by vomiting and diarrhoea, which contributes to the high case-fatality. Fluid administration is considered to be a key part of supportive care although the usefulness of enteral rehydration is often limited in these patients. Parenteral fluid administration may be the only way to administer enough fluids to prevent dehydration. Due to the highly infectious nature of EVD, is it essential that the parenteral route (i.e. intravenous, intraosseous, subcutaneous, or intraperitoneal) used to administer fluids is simple and quick to insert, and is maintained with minimal clinical intervention. This systematic review will compare the reliability, ease of use and speed of insertion of different parenteral access methods.


PROSPERO is an international database of prospectively registered systematic reviews in health and social care. The following two articles are scheduled for publication around the end of 2014/start of 2015. Both articles will be Open Access.

Behavioural and self-management prevention interventions for people at risk of contracting Ebola: a systematic review. The aim of this review is to identify existing studies which have sought to examine the impact of behavioural (including education for behaviour change) or self-management interventions. In particular we want to examine interventions which prevent or have an impact on the survival rates or transmission rates of Ebola, with the aim of reducing incidence and prevalence of the disease in the most vulnerable communities. We hope to identify not only effective interventions but interventions which are culturally sensitive, that is, interventions which compliment traditional ways of living and not eradicate them, which may enhance adoption and longevity of the intervention.

Structural adjustment and the impact on those people at risk of contracting Ebola: a systematic review. The aim of this review is to identify existing studies which have sought to examine the impact of structural adjustments on survival rates, also the the incidence and prevalence of Ebola. By structural interventions we mean changes to health care organisation and/or service delivery; we also want to assess the impact of recently introduced health surveillance and monitoring systems. Given the multi-national and multi-agent involvement in the current outbreak and the involvement of international financial organisations we also want to examine the impact of tax reform, and changes to domestic or environmental policy, which may be legislated by governmental or encouraged by non-governmental organisations.

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