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Interventions for treating phosphorus burns

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First aid for phosphorus burns involves the common sense measures of acting promptly to remove the patient’s clothes, irrigating the wound(s) with water or saline continuously, and removing phosphorus particles. There is no evidence that using copper sulphate to assist visualisation …

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High-carbohydrate, high-protein, low-fat versus low-carbohydrate, high-protein, high-fat enteral feeds for burns

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The available evidence suggests that use of high-carbohydrate, high-protein, low-fat enteral feeds in patients with at least 10% total body surface area burns might reduce the incidence of pneumonia compared with use of a low-carbohydrate, high-protein, high-fat diet. The available evidence is …

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Selenium supplementation for critically ill adults

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There is limited evidence to recommend supplementation of critically ill patients with selenium or ebselen.
Selenium is a trace mineral essential to health and has an important role in immunity, defence against tissue damage and thyroid function. Improving selenium status could help …

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Nutritional support for critically ill children

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The one trial included in this review was of low methodological quality and found no statistically significant difference for mortality, sepsis, ventilator days, length of stay, unexpected adverse events, resting energy expenditure, nitrogen balance, or albumin levels.
Nutritional support in the critically …

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Early versus delayed enteral nutrition support for burn injuries

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This systematic review has not found sufficient evidence to support or refute the effectiveness of early versus late enteral nutrition support in adults with burn injury. The trials showed some promising results that would suggest early enteral nutrition support may blunt the …

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Intravenous lidocaine for the treatment of background or procedural burn pain

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As current clinical evidence is based on only one single randomised controlled trial as well as case series and reports, intravenous lidocaine must be considered a pharmacological agent under investigation in burns care, the effectiveness of which is yet to be determined …

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Hyperbaric oxygen therapy for thermal burns

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There is insufficient evidence to support or refute the effectiveness of hyperbaric oxygen therapy (HBOT) for the management of thermal burns.
HBOT consists of intermittently administering 100% oxygen at pressures greater than 1 atmosphere in a pressure vessel. This technology has been used …

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Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

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There is no current evidence to support or refute the routine use of aerosolized prostacyclin for patients with acute lung injury (ALI) and acute respiratory distress (ARDS).
ALI and ARDS are critical conditions that are associated with high mortality and morbidity. Aerosolised prostacyclin …

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Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care

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A combination of topical and systemic prophylactic antibiotics reduces respiratory tract infections and overall mortality in adult patients receiving intensive care. Treatment based on the use of topical prophylaxis alone reduces respiratory infections but not mortality. The risk of resistance occurring as …

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Antithrombin III for critically ill patients

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Antithrombin III (AT III) cannot be recommended for critically ill patients based on the available evidence.
Critical illness is associated with uncontrolled inflammation and vascular damage which can result in multiple organ failure and death. AT III is an anticoagulant with anti-inflammatory …

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