» Neonates/infants

Probiotics for treating acute infectious diarrhoea

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Used alongside rehydration therapy, probiotics appear to be safe and have clear beneficial effects in shortening the duration and reducing stool frequency in acute infectious diarrhoea. However, more research is needed to guide the use of particular probiotic regimens in specific patient …

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Oral zinc for treating diarrhoea in children

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In areas where the prevalence of zinc deficiency or the prevalence of moderate malnutrition is high, zinc may be of benefit in children aged six months or more.The current evidence does not support the use of zinc supplementation in children below six …

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Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children

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There were no important clinical differences between oral rehydration therapy and intravenous rehydration therapy for rehydration secondary to acute gastroenteritis in children.
Dehydration associated with gastroenteritis is a serious complication. Dehydration occurs when body water content is reduced causing dry skin, headaches, sunken …

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Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children

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In children admitted to hospital with diarrhoea, reduced osmolarity ORS [total osmolarity ≤ 250 mmol/L with reduced sodium] when compared to WHO standard ORS [90 mmol/L sodium, 111 mmol/L glucose, total osmolarity 311 mmol/L] is associated with fewer unscheduled intravenous fluid infusions, …

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Antibiotics versus placebo for acute bacterial conjunctivitis

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Acute bacterial conjunctivitis is frequently a self-limiting condition, but the use of antibiotics is associated with modestly improved rates of clinical and microbiological remission compared to placebo.
Acute bacterial conjunctivitis is an infective condition in which the eyes become red and inflamed. …

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Antimicrobials for treating symptomatic non-typhoidal Salmonella infection

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There appears to be no evidence of a clinical benefit of antibiotic therapy in otherwise healthy children and adults with non-severe salmonella diarrhoea. Antibiotics appear to increase adverse effects and they also tend to prolong salmonella detection in stools.
Non-typhoidal salmonellosis appears …

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Oral rehydration salt solution for treating cholera: ≤ 270 mOsm/L solutions vs ≥ 310 mOsm/L solutions

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In people with cholera, ORS ≤ 270 is associated with biochemical hyponatraemia when compared with ORS ≥ 310 [90 mmol/L of sodium, 20 mmol/L of potassium, 80 mmol/L of chloride, 10 mmol/L of citrate, and 111 mmol/L of glucose, with a …

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Polymer-based oral rehydration solution for treating acute watery diarrhoea

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Polymer-based ORS shows some advantages compared to ORS ≥ 310 [the original ORS was based on glucose and had an osmolarity of ≥ 310 mOsm/L] for treating all-cause diarrhoea, and in diarrhoea caused by cholera. Comparisons favoured the polymer-based ORS over …

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Interventions to improve water quality for preventing diarrhoea

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Interventions to improve water quality are generally effective in preventing diarrhoea, and interventions to improve water quality at the household level are more effective than those at the source.
Diarrhoeal diseases are a leading cause of mortality and morbidity, especially among young children …

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