» Population displacement

Oral treatments for fungal infections of the skin of the foot

Read the full review here
The evidence suggests that terbinafine is more effective than griseofulvin and that terbinafine and itraconazole are more effective than no treatment.
About 15% of the population have fungal infections of the feet (tinea pedis or athlete’s foot). While there are many clinical …

Full Story »

Topical treatments for fungal infections of the skin and nails of the foot

Read the full review here
Placebo-controlled trials of allylamines and azoles for athlete’s foot consistently produce much higher percentages of cure than placebo. Allylamines cure slightly more infections than azoles and are now available OTC [over the counter]. Further research into the effectiveness of antifungal agents …

Full Story »

Antibiotics versus placebo for acute bacterial conjunctivitis

Read the full review here
Acute bacterial conjunctivitis is frequently a self-limiting condition, but the use of antibiotics is associated with modestly improved rates of clinical and microbiological remission compared to placebo.
Acute bacterial conjunctivitis is an infective condition in which the eyes become red and inflamed. …

Full Story »

Interventions for impetigo

Read the full review here
There is good evidence that topical mupirocin and topical fusidic acid are equally, or more, effective than oral treatment. Due to the lack of studies in people with extensive impetigo, it is unclear if oral antibiotics are superior to topical antibiotics …

Full Story »

Interventions for treating scabies

Read the full review here
On the basis of the available evidence from randomized controlled trials, topical permethrin appears to be the most effective treatment for scabies. Ivermectin appears to be an effective oral treatment, but in many countries it is not licensed for this indication.
Scabies …

Full Story »

Oral rehydration salt solution for treating cholera: ≤ 270 mOsm/L solutions vs ≥ 310 mOsm/L solutions

Read the full review here
In people with cholera, ORS ≤ 270 is associated with biochemical hyponatraemia when compared with ORS ≥ 310 [90 mmol/L of sodium, 20 mmol/L of potassium, 80 mmol/L of chloride, 10 mmol/L of citrate, and 111 mmol/L of glucose, with a …

Full Story »

Polymer-based oral rehydration solution for treating acute watery diarrhoea

Read the full review here
Polymer-based ORS shows some advantages compared to ORS ≥ 310 [the original ORS was based on glucose and had an osmolarity of ≥ 310 mOsm/L] for treating all-cause diarrhoea, and in diarrhoea caused by cholera. Comparisons favoured the polymer-based ORS over …

Full Story » Comment (1)

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

Read the full review here
Xpert® MTB/RIF used as initial diagnostic test for TB detection in patients suspected of having TB, MDR-TR or HIV-associated TB is sensitive and specific. Compared with smear microscopy, Xpert® MTB/RIF substantially increases TB detection among culture-confirmed cases. Xpert® MTB/RIF may also …

Full Story »

Surgical versus conservative interventions for displaced intra-articular calcaneal fractures

Read the full article
There is insufficient high quality evidence to establish whether surgical or conservative treatment is better for adults with displaced intra-articular calcaneal (heel bone) fracture.
Fractures of the calcaneus (heel bone) comprise up to 2% of all fractures, and are mostly caused by a …

Full Story »

Water for wound cleansing

Read the full review here
There is no evidence that using potable tap water to cleanse acute wounds in adults increases infection, and there is some evidence that it reduces infection. However, there is not strong evidence that cleansing wounds per se increases healing or reduces …

Full Story »